反应详情

Under the conditions of example 1 B, a solution of 22 g of 2-iodo-3-methoxypyridine-6-carboxylic acid methyl ester in 50 ml of dimethylformamide is reacted with 12.6 g of acrylic acid methyl ester in the presence of 5.3 g of bis-triphenylphosphinepalladium(II) chloride, 25.9 g of potassium carbonate and 23.4 g of tetrabutylammonium bromide, worked up, and the crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 11 g of 3-(3-methoxy-6-methoxycarbonyl-2-pyridyl)-(2E)-2-propenoic acid methyl ester of melting point 123°-126° C. is obtained.

1. customthe crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate