Borane → Methyl 2''-(hydroxymethyl)-4'-methoxy-2-methyl-4''-(trifluoromethyl)-1,1':3', 1''-terphenyl-4-carboxylate

Temperature

80 °C

To methyl 3′-bromo-4′-methoxy-2-methylbiphenyl-4-carboxylate (80.0 g, 0.239 mol), pinacole borane (72.8 g, 0.287 mol), Pd(dba)2 (4120 mg, 7.17 mmol), P(Cy)3 (2140 mg, 7.65 mmol), and KOAc (70.3 g, 0.717 mol) was added dioxane (1.2 L). The reaction was heated to 80° C. and stirred for 3 hours. The reaction was then cooled to room temperature and filtered. The solids were dissolved with EtOAc (800 mL), washed with brine (400 mL, twice), and concentrated. The residue was dissolved in THF (300 mL), and [2-chloro-5-(trifluoromethyl)phenyl]methanol (47.1 g, 0.223 mol) and (t-Bu2P)2ferrocene PdCl2 were added. A solution of K2CO3 (83.7 g, 0.606 mol in water (214 mL) was added and the mixture was heated to 45° C. and stirred for 9 hours. The reaction was cooled to room temperature and diluted with EtOAc (428 mL), and washed with water (428 mL) and brine (428 mL). To the organic material was added 21.5 g charcoal (Darco KB −100 mesh) and the mixture was stirred for 1 hour. The mixture was filtered, and the solid material was washed with EtOAc (428 mL). The filtrate was concentrated and then re-dissolved in MeOH (677 mL) and left to stand for 1 hour. To the mixture was added water (169 mL) over 2 hours, and then the mixture was left to stand for 1 hour. The resulting solids were washed with a solution of MeOH and water (4:1, 170 mL, three times) and dried to afford methyl 2″-(hydroxymethyl)-4′-methoxy-2-methyl-4″-(trifluoromethyl)-1,1′:3′,1″-terphenyl-4-carboxylate.

1. temperatureThe reaction was then cooled to room temperature
2. filtrationfiltered
3. dissolutionThe solids were dissolved with EtOAc (800 mL)
4. washwashed with brine (400 mL
5. concentrationtwice), and concentrated
6. dissolutionThe residue was dissolved in THF (300 mL)
7. temperaturethe mixture was heated to 45° C.
8. stirringstirred for 9 hours
9. temperatureThe reaction was cooled to room temperature
10. washwashed with water (428 mL) and brine (428 mL)
11. additionTo the organic material was added 21.5 g charcoal (Darco KB −100 mesh)
12. stirringthe mixture was stirred for 1 hour
13. filtrationThe mixture was filtered
14. washthe solid material was washed with EtOAc (428 mL)
15. concentrationThe filtrate was concentrated
16. dissolutionre-dissolved in MeOH (677 mL)
17. waitleft
18. waitto stand for 1 hour
19. additionTo the mixture was added water (169 mL) over 2 hours
20. waitthe mixture was left
21. waitto stand for 1 hour
22. washThe resulting solids were washed with a solution of MeOH and water (4:1, 170 mL, three times)
23. customdried

ORD record

ord-20b4ecf349ca4f13834b666afb9000f9

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07915271B2