Ethyl 2-chloroacetoacetate → HCID 54697139, compound

HRID 621788Notes

Reaction equation

HRID 621788 reaction equation
[Cl:1][CH:2]([C:8]([CH3:10])=O)[C:3](OCC)=[O:4].[C:11]([O:15][CH3:16])(=[O:14])[CH2:12][SH:13].[Na]>C(O)(C)C>[OH:4][C:3]1[C:2]([Cl:1])=[C:8]([CH3:10])[S:13][C:12]=1[C:11]([O:15][CH3:16])=[O:14]

Participants

5

Reactant 3

HCID 11858Ethyl 2-chloroacetoacetateHCID 16907Methyl ThioglycolateHCID 5360545Sodium

Product 1

HCID 54697139HCID 54697139, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared by the method described in Example 1 from ethyl α-chloroacetoacetate (59 g, 0.35 moles), methyl thioglycolate (102 g, 0.70 moles) and sodium (19.7 g, 0.86 moles). The product is obtained from the crystalline precipitate by fractional recrystallization from isopropanol to give 2.8 g; mp 105°-107° C.

Workup

  1. customPrepared by the method
  2. customto give 2.8 g

Sources & evidence

ORD record
ord-33ad1e293a3e464d9e4c8db34ade3243
Source dataset
uspto-grants-1989_04
Patent number
US04824958

Reaction notes

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