Hydrochloric Acid → (3-Amino-5-chloro-2-cyclopropylcarbamoyl-4-methyl-thieno[2,3-b]pyridin-6-yloxy)-acetic acid 2-hydroxyethylamide

HRID 664625Notes

Reaction equation

HRID 664625 reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH3:45][N:46]([CH3:47])[CH2:48][CH2:49][CH2:50][N:51]=[C:52]=[N:53][CH2:54][CH3:55].[CH:35]([N:36]([CH2:37][CH3:38])[CH:39]([CH3:40])[CH3:41])([CH3:42])[CH3:43].[ClH:44].[NH2:1][c:2]1[c:3]([C:18]([NH:19][CH:20]2[CH2:21][CH2:22]2)=[O:23])[s:4][c:5]2[n:6][c:7]([O:13][CH2:14][C:15](=[O:16])[OH:17])[c:8]([Cl:12])[c:9]([CH3:11])[c:10]12.[NH2:56][CH2:57][CH2:58][OH:59].[O:60]=[CH:61][N:62]([CH3:63])[CH3:64].[OH2:24].[OH:25][n:26]1[c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1>>[NH2:1][c:2]1[c:3]([C:18]([NH:19][CH:20]2[CH2:21][CH2:22]2)=[O:23])[s:4][c:5]2[n:6][c:7]([O:13][CH2:14][C:15](=[O:16])[NH:56][CH2:57][CH2:58][OH:59])[c:8]([Cl:12])[c:9]([CH3:11])[c:10]12

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 962WaterHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 68436813(3-Amino-5-chloro-2-cyclopropylcarbamoyl-4-methyl-thieno[2,3-b]pyridin-6-yloxy)-acetic acid

Product 1

HCID 57664409(3-Amino-5-chloro-2-cyclopropylcarbamoyl-4-methyl-thieno[2,3-b]pyridin-6-yloxy)-acetic acid 2-hydroxyethylamide

Sources & evidence

ORD record
ord-b88be9e656bf400481ff565fcdf0a56e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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