Tetrahydrofuran → 2-(2-Chlorophenylamino)-3,4-difluoro-5-trimethylsilanylethynylbenzoic acid methyl ester

HRID 684531Notes

Reaction equation

HRID 684531 reaction equation
[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:1][O:2][C:3]([c:4]1[c:5]([NH:13][c:14]2[c:15]([Cl:20])[cH:16][cH:17][cH:18][cH:19]2)[c:6]([F:12])[c:7]([F:11])[c:8]([Br:10])[cH:9]1)=[O:21].[Cu:74][I:75].[Pd:33]([Cl:34])[Cl:35].[Si:22]([CH3:23])([CH3:24])([CH3:25])[C:26]#[CH:27].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][cH:51][cH:52][cH:53][cH:54]1.[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[CH3:1][O:2][C:3]([c:4]1[c:5]([NH:13][c:14]2[c:15]([Cl:20])[cH:16][cH:17][cH:18][cH:19]2)[c:6]([F:12])[c:7]([F:11])[c:8]([C:27]#[C:26][Si:22]([CH3:23])([CH3:24])[CH3:25])[cH:9]1)=[O:21]

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 865967715-Bromo-2-(2-chlorophenylamino)-3,4-difluorobenzoic acid methyl ester

Product 1

HCID 865967722-(2-Chlorophenylamino)-3,4-difluoro-5-trimethylsilanylethynylbenzoic acid methyl ester

Sources & evidence

ORD record
ord-9dc13fdf91ce448b8bfa17901f5f50a4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…