反应详情

3.64 g (20 mmol) of 4-bromobenzonitrile and 2.88 g (40 mmol) of acrylic acid were dissolved in 40 ml of acetonitrile. 49 mg (0.2 mmol) of palladium (II) acetate, 365 mg (1.2 mmol) of tri-o-tolylphosphine and 7.41 g (40 mmol) of tributylamine were added to the solution, and they were heated under reflux overnight. The reaction liquid was poured into 4 N aqueous hydrogen chloride solution. The precipitates thus formed were taken by the filtration, washed with 4 N aqueous hydrogen chloride solution, water and ethyl acetate, and then dried in vacuo to obtain the title compound.

1. temperaturewere heated
2. temperatureunder reflux overnight
3. customThe reaction liquid
4. customThe precipitates thus
5. customformed
6. filtrationwere taken by the filtration
7. washwashed with 4 N aqueous hydrogen chloride solution, water and ethyl acetate
8. customdried in vacuo