Dimethylcarbamoyl Chloride → HCID 131726963, compound

HRID 747796Notes

Reaction equation

HRID 747796 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:11])#[N:2].C(N(CC)CC)C.[CH3:29][N:30]([CH3:34])[C:31](Cl)=[O:32].C(OCC)(=O)C>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([CH2:12][CH:13]1[CH2:14][CH2:15][N:16]([C:31]([N:30]([CH3:34])[CH3:29])=[O:32])[CH2:17][CH2:18]1)=[O:11])#[N:2]

Participants

6

Reactant 4

HCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 131726959HCID 131726959, compound

Product 1

HCID 131726963HCID 131726963, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

430 mg (1.58 mmol) of N-[2-(3-cyanophenoxy)ethyl]-piperidine-4-carboxyamide (JP2 19-1) was dissolved in 1.6 ml of dimethylformamide, and 0.3 ml (2.06 mmol) of triethylamine and 0.16 ml (1.74 mmol) of dimethyl carbamoyl chloride were added thereto at 0° C. and stirred at room temperature for 2 hours. It was treated in an ordinary manner with ethyl acetate as the extractant to obtain the title compound.

Sources & evidence

ORD record
ord-ccfa8459e0b549ee94fec89631949a0c
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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