Tetrahydrofuran → 2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine

HRID 821242Notes

Reaction equation

HRID 821242 reaction equation
[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH2:39]([N:40]([CH2:41][CH3:42])[CH2:43][CH3:44])[CH3:45].[CH3:28][Si:29]([CH3:30])([CH3:31])[C:32]#[CH:33].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([I:8])[cH:7]1.[Cu:46][I:47].[c:9]1([P:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:33]#[C:32][Si:29]([CH3:28])([CH3:30])[CH3:31])[cH:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 15165112-Chloro-4-iodopyridine

Product 1

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine

Sources & evidence

ORD record
ord-ce1565765be3446a898631be96302161
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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