Water → Ethyl 6,7,9,10-tetrahydro-4-oxo-10-[(2-pyridinylcarbonyl)amino]-2-(4-pyrimidinyl)pyrimido[1,2-d][1,4]diazepine-8(4H)-carboxylate

HRID 822378Notes

Reaction equation

HRID 822378 reaction equation
[C:34]([P:35](=[O:36])([O:37][CH2:38][CH3:39])[O:40][CH2:41][CH3:42])#[N:43].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][n:9]2[c:10]([n:14][c:15](-[c:19]3[n:20][cH:21][n:22][cH:23][cH:24]3)[cH:16][c:17]2=[O:18])[CH:11]([NH2:13])[CH2:12]1.[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH3:51][N:52]([CH3:53])[CH:54]=[O:55].[CH3:56][CH2:57][O:58][C:59](=[O:60])[CH3:61].[OH2:62].[n:25]1[c:26]([C:31](=[O:32])[OH:33])[cH:27][cH:28][cH:29][cH:30]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][n:9]2[c:10]([n:14][c:15](-[c:19]3[n:20][cH:21][n:22][cH:23][cH:24]3)[cH:16][c:17]2=[O:18])[CH:11]([NH:13][C:31]([c:26]2[n:25][cH:30][cH:29][cH:28][cH:27]2)=[O:32])[CH2:12]1

Participants

8

Reactant 7

HCID 962WaterHCID 1018Picolinic acidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 76257Diethyl cyanophosphonateHCID 669298339-amino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4-a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester

Product 1

HCID 44158890Ethyl 6,7,9,10-tetrahydro-4-oxo-10-[(2-pyridinylcarbonyl)amino]-2-(4-pyrimidinyl)pyrimido[1,2-d][1,4]diazepine-8(4H)-carboxylate

Sources & evidence

ORD record
ord-d60074556512472cbea3b53c45a8710a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…