1,2-Dichloroethane → 1-(Pyridin-2-ylmethyl)piperidin-3-ol

HRID 836823Notes

Reaction equation

HRID 836823 reaction equation
[C:17]([O:18][BH-:19]([O:20][C:21](=[O:22])[CH3:23])[O:24][C:25](=[O:26])[CH3:27])(=[O:28])[CH3:29].[CH3:38][C:39](=[O:40])[OH:41].[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:33][CH2:34][CH2:35][Cl:36].[ClH:1].[NH:2]1[CH2:3][CH:4]([OH:8])[CH2:5][CH2:6][CH2:7]1.[Na+:30].[Na+:32].[OH-:31].[OH2:37].[n:9]1[c:10]([CH:15]=[O:16])[cH:11][cH:12][cH:13][cH:14]1>>[N:2]1([CH2:15][c:10]2[n:9][cH:14][cH:13][cH:12][cH:11]2)[CH2:3][CH:4]([OH:8])[CH2:5][CH2:6][CH2:7]1

Participants

11

Reactant 10

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 961HydroxideHCID 962WaterHCID 8471TriethylamineHCID 142732-PyridinecarboxaldehydeHCID 232933-HydroxypiperidineHCID 2724942Triacetoxyborohydride

Product 1

HCID 35569511-(Pyridin-2-ylmethyl)piperidin-3-ol

Sources & evidence

ORD record
ord-1847e425d9824fdf937222b8b00cb4d8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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