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HRID84177

反应详情

EQUATION

反应方程式

HRID 84177 的结构方程式

REACTANTS

反应物

7
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=S(=O)(Cl)c1ccccc1
HCID7369

Benzenesulfonyl chloride

C6H5ClO2S

结构：ClCc1ccccc1
HCID7503

Benzyl chloride

C7H7Cl

结构：F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
HCID2724699

PyBOP

C18H28F6N6OP2

结构：NOC1CCCCO1
HCID5142091

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

C5H11NO2

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

1
结构：O=C(NO)c1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1
HCID53464575

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

4
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Compound 1 was synthesized via the route as shown in Scheme 1 above (reagents and conditions: a) benzyl chloride or benzenesulfonyl chloride, t-BuOK, KI, DMF; b) 1M LiOH(aq), dioxane; c) (i) NH2OTHP, PyBOP, NEt3, DMF, rt; (ii) TFA, MeOH, rt).