Chloride → Methyl 2-(2-chloro-4-fluorophenyl)-4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

HRID 940509Notes

Reaction equation

HRID 940509 reaction equation
[CH2:34]([CH3:35])[O:36][C:37]([CH2:38][C:39]([O-:40])=[O:41])=[O:42].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:48].[Cl-:44].[Cl-:46].[Cl:1][c:2]1[c:3]([CH:9]2[N:10]([C:18](=[O:19])[O:20][CH3:21])[CH2:11][CH2:12][CH:13]([C:15](=[O:16])[OH:17])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Cl:54][CH2:55][Cl:56].[ClH:47].[K+:43].[Mg+2:45].[n:22]1([C:23]([n:24]2[cH:25][cH:26][n:27][cH:28]2)=[O:29])[cH:30][cH:31][n:32][cH:33]1>>[Cl:1][c:2]1[c:3]([CH:9]2[N:10]([C:18](=[O:19])[O:20][CH3:21])[CH2:11][CH2:12][CH:13]([C:15](=[O:17])[CH2:38][C:37]([O:36][CH2:34][CH3:35])=[O:42])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

11

Reactant 10

HCID 312Chloride2×HCID 313Hydrochloric AcidHCID 813Potassium CationHCID 888Magnesium CationHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 3034819MethylHCID 3595298Propanedioic acid, monoethyl esterHCID 66731707HCID 66731707, compound

Product 1

HCID 66731881Methyl 2-(2-chloro-4-fluorophenyl)-4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-909ab3f5b7cf46e1b84bb9d50eef37c6
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…