Sodium ion → 2-Chloro-4-[7-(2-chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-pyrimidine

HRID 941144Notes

Reaction equation

HRID 941144 reaction equation
[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH:17]([O:18][B:19]([O:20][CH:21]([CH3:22])[CH3:23])[O:24][CH:25]([CH3:26])[CH3:27])([CH3:28])[CH3:29].[CH:30]([N-:31][CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[CH:57]([OH:58])([CH3:59])[CH3:60].[CH:61]([Cl:62])([Cl:63])[Cl:64].[Cl:38][c:39]1[n:40][cH:41][cH:42][c:43]([Cl:45])[n:44]1.[Li+:37].[Na+:46].[Na+:47].[O-:48][C:49](=[O:50])[O-:51].[OH2:65].[s:1]1[c:2]2[c:3]([cH:4][cH:5]1)[cH:6][cH:7][cH:8][c:9]2-[c:10]1[cH:11][c:12]([Cl:16])[n:13][cH:14][cH:15]1>>[s:1]1[c:2]2[c:3]([cH:4][c:5]1-[c:43]1[cH:42][cH:41][n:40][c:39]([Cl:38])[n:44]1)[cH:6][cH:7][cH:8][c:9]2-[c:10]1[cH:11][c:12]([Cl:16])[n:13][cH:14][cH:15]1

Participants

12

Reactant 11

HCID 923Sodium ion2×HCID 962WaterHCID 3776IsopropanolHCID 6212ChloroformHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 21531Triisopropyl borateHCID 28486Lithium ionHCID 775312,4-DichloropyrimidineHCID 5062348DiisopropylamideHCID 866402544-Benzo[b]thiophen-7-yl-2-chloro-pyridine

Product 1

HCID 866402552-Chloro-4-[7-(2-chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-pyrimidine

Sources & evidence

ORD record
ord-9ee7fe4cde374dcea67b5d7dcdac5681
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…