Tetrahydrofuran → HCID 57678393, compound
Reaction equation
[CH2:80]1[O:81][CH2:82][CH2:83][CH2:84]1.[CH3:22][Si:23]([CH3:24])([CH3:25])[C:26]#[CH:27].[CH:28]([N:29]([CH:30]([CH3:31])[CH3:32])[CH2:33][CH3:34])([CH3:35])[CH3:36].[Cu:78][I:79].[I:1][c:2]1[c:3]([O:20][CH3:21])[cH:4][c:5]([CH:17]([CH3:18])[CH3:19])[c:6]([O:7][c:8]2[c:9]([NH2:15])[n:10][c:11]([NH2:14])[n:12][cH:13]2)[cH:16]1.[Pd:37]([Cl:38])[Cl:39].[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1.[c:59]1([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[c:2]1([C:27]#[C:26][Si:23]([CH3:22])([CH3:24])[CH3:25])[c:3]([O:20][CH3:21])[cH:4][c:5]([CH:17]([CH3:18])[CH3:19])[c:6]([O:7][c:8]2[c:9]([NH2:15])[n:10][c:11]([NH2:14])[n:12][cH:13]2)[cH:16]1Participants
8
Reactant 7
HCID 8028Tetrahydrofuran
HCID 11776Triphenylphosphine2×
HCID 24290Palladium Chloride
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 66111Trimethylsilylacetylene
HCID 81531Diisopropylethylamine
HCID 159538025-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamineProduct 1
Sources & evidence
- ORD record
- ord-afa761124c5a49e98717bb831f257fa3
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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