Tetrahydrofuran → 4-[2-(Trimethylsilyl)ethynyl]pyridine-2-carbonitrile

HRID 957058Notes

Reaction equation

HRID 957058 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]#[N:9])[n:5][cH:6][cH:7]1.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:29][Si:30]([CH3:31])([CH3:32])[C:33]#[CH:34].[Cu:40][I:41].[c:10]1([P:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[c:2]1([C:34]#[C:33][Si:30]([CH3:29])([CH3:31])[CH3:32])[cH:3][c:4]([C:8]#[N:9])[n:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 6932834-Bromo-2-cyanopyridine

Product 1

HCID 451164464-[2-(Trimethylsilyl)ethynyl]pyridine-2-carbonitrile

Sources & evidence

ORD record
ord-2eb74ffe14a04795853b2eb195c5b94a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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