Toluene → Diisopropylethylamine

HRID 968965Notes

Reaction equation

HRID 968965 reaction equation
C(Cl)Cl.O1[CH2:8][CH2:7][CH2:6]C1.[C:9]1([CH3:15])[CH:14]=CC=CC=1.C(OCC)(=O)C.[CH2:22]([N:24](CC)CC)[CH3:23]>C(Cl)(Cl)Cl.N1C=CC=CC=1>[CH:7]([N:24]([CH2:22][CH3:23])[CH:9]([CH3:14])[CH3:15])([CH3:8])[CH3:6]

Participants

8

Reactant 5

HCID 1140TolueneHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl Acetate

Product 1

HCID 81531Diisopropylethylamine

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6212ChloroformSolvent

Procedure

By reacting compound (XIIIB) obtained in Step 9B with compound (XVIIIB) in chloroform, methylene chloride, tetrahydrofuran, toluene, ethyl acetate, or a mixed solvent thereof, in the presence of a base such as pyridine, triethylamine, N,N-diisopropylethylamine and the like, compound (1-4) can be obtained.

Sources & evidence

ORD record
ord-0fb7afe6f15e473e8a6f9095b9bd0fc7
Source dataset
uspto-grants-2007_12
Patent number
US07304174B2

Reaction notes

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