反应详情

温度

150 °C

A mixture of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4)3H)-one (1.5 g, 0.0099 mol), 2-chloro-3-(trifluoromethyl)pyridine (2.7 g, 0.015 mol) and N,N-diisopropylethylamine (2.6 mL, 0.015 mol) in N-methylpyrrolidinone (9 mL, 0.09 mol) was heated in a sealed vessel via microwave at 150° C. for 2 hours. After cooling to rt, the reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (4×30 mL). The combined extracts were washed with brine and dried over magnesium sulfate and concentrated to dryness to leave a yellow solid which was taken on without futher purification. The solid (1.00 g, 0.00338 mol), Phosphoryl chloride (1.19 mL, 0.0127 mol) and N,N-Dimethylaniline (0.202 mL, 0.00159 mol) in 1,2-Dichloroethane (20 mL) was heated to reflux for 3 hours. The mixture was concentrated under reduced pressure to leave a black oil. Residue was taken up in dichloromethane (50 mL) and poured over crushed ice. Mixture slowly neutralized by addition of solid sodium bicarbonate. The layers were separated and organic layer dried over magnesium sulfate and concentrated to leave a dark brown oil Purified by flash chromatography over silica gel (ethyl acetate/hexane gradient 0 to 100%) to yield the desired product as a yellow solid (0.716 g).

1. temperatureAfter cooling to rt
2. extractionextracted with ethyl acetate (4×30 mL)
3. washThe combined extracts were washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated to dryness
6. customto leave a yellow solid which
7. customwas taken on without futher purification
8. temperatureto reflux for 3 hours
9. concentrationThe mixture was concentrated under reduced pressure
10. customto leave a black oil
11. additionpoured
12. customover crushed ice
13. customThe layers were separated
14. dry with materialorganic layer dried over magnesium sulfate
15. concentrationconcentrated
16. customto leave a dark brown oil
17. customPurified by flash chromatography over silica gel (ethyl acetate/hexane gradient 0 to 100%)