Hydrochloric Acid → 4-Methylmorpholine

HRID 986381Notes

Reaction equation

HRID 986381 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:20].[CH3:21][CH2:22][O:23][C:24]([CH3:26])=O>CN(C=O)C>[NH2:1][C@H:2]([C:10]([NH2:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:20].[CH3:2][N:1]1[CH2:26][CH2:24][O:23][CH2:22][CH2:21]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 7020416Boc-L-phenylalaninamide

Product 2

HCID 79724-MethylmorpholineHCID 11953719Phenylalanine amide hydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Two minutes later, a solution of PheNH2HCl (1.2 g, 0.6 mmol), obtained by cleavage of the t-butoxycarbonyl group from BocPheNH2 with 4.5N HCl in EtOAc, and NMM (0.6 g, 6 mmoles) in DMF is added thereto.

Sources & evidence

ORD record
ord-15d54b42db1843fa8f2350d08cfc59bf
Source dataset
uspto-grants-1987_12
Patent number
US04713367

Reaction notes

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