Hydrochloric Acid → N-[5-(4,5-dihydro-1,3-thiazol-2-yl)-2-methyl-4H-thieno[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

HRID 1115670Notes

Reaction equation

HRID 1115670 reaction equation
[C:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[S:43][CH2:44][CH2:45][NH2:46].[CH3:108][N:109]([CH3:110])[CH:111]=[O:112].[CH3:113][CH2:114][N:115]([CH2:116][CH3:117])[CH2:118][CH3:119].[CH3:1][c:2]1[c:3]([N:13]([S:14](=[O:15])(=[O:16])[c:17]2[s:18][cH:19][cH:20][cH:21]2)[CH3:22])[c:4]2[nH:5][c:6]([C:10]([OH:11])=[O:12])[cH:7][c:8]2[s:9]1.[CH3:58][N:59]([CH3:60])[CH2:61][CH2:62][CH2:63][N:64]=[C:65]=[N:66][CH2:67][CH3:68].[Cl:104][CH2:105][Cl:106].[ClH:23].[ClH:57].[F:89][C:90]([S:91]([O:92][S:93]([C:94]([F:95])([F:96])[F:97])(=[O:98])=[O:99])(=[O:100])=[O:101])([F:102])[F:103].[OH2:107].[c:69]1([P:70](=[O:71])([c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[cH:84][cH:85][cH:86][cH:87][cH:88]1.[n:47]1([OH:48])[c:49]2[cH:50][cH:51][cH:52][cH:53][c:54]2[n:55][n:56]1>>[CH3:1][c:2]1[c:3]([N:13]([S:14](=[O:15])(=[O:16])[c:17]2[s:18][cH:19][cH:20][cH:21]2)[CH3:22])[c:4]2[nH:5][c:6]([C:10]3=[N:46][CH2:45][CH2:44][S:43]3)[cH:7][c:8]2[s:9]1

Participants

12

Reactant 11

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 13097Triphenylphosphine OxideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 67749Trifluoromethanesulfonic anhydrideHCID 757711-HydroxybenzotriazoleHCID 262764S-TritylcysteamineHCID 594113852-methyl-3-[methyl(2-thienylsulfonyl)amino]-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Product 1

HCID 24772047N-[5-(4,5-dihydro-1,3-thiazol-2-yl)-2-methyl-4H-thieno[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

Sources & evidence

ORD record
ord-e5148b074a2140648fd3e52de25dfe00
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…