Tetrahydrofuran → HCID 22287521, compound

HRID 1127377Notes

Reaction equation

HRID 1127377 reaction equation
[Br:33][c:34]1[c:35]([NH:53][C:54]([C:55]([C:56]([F:57])([F:58])[F:59])([CH3:60])[OH:61])=[O:62])[cH:36][cH:37][c:38]([S:40](=[O:41])(=[O:42])[c:43]2[cH:44][cH:45][c:46]([S:49](=[O:50])(=[O:51])[CH3:52])[cH:47][cH:48]2)[cH:39]1.[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[CH3:111][CH2:112][O:113][C:114](=[O:115])[CH3:116].[CH3:20][Si:21]([CH3:22])([CH3:23])[C:24]#[CH:25].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[Cu:68][I:69].[Pd:70]([Cl:71])[Cl:72].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1.[c:73]1([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[cH:87][cH:88][cH:89][cH:90][cH:91]1.[c:92]1([P:93]([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[cH:106][cH:107][cH:108][cH:109][cH:110]1>>[CH3:20][Si:21]([CH3:22])([CH3:23])[C:24]#[C:25][c:34]1[c:35]([NH:53][C:54]([C:55]([C:56]([F:57])([F:58])[F:59])([CH3:60])[OH:61])=[O:62])[cH:36][cH:37][c:38]([S:40](=[O:41])(=[O:42])[c:43]2[cH:44][cH:45][c:46]([S:49](=[O:50])(=[O:51])[CH3:52])[cH:47][cH:48]2)[cH:39]1

Participants

9

Reactant 8

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine3×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 22287170HCID 22287170, compound

Product 1

HCID 22287521HCID 22287521, compound

Sources & evidence

ORD record
ord-f44b825c298b45048856c63cf207a6f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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