Hydrochloric Acid → N-methyl-1-[4-oxo-8-[2-(4-propan-2-yl-1,3-thiazol-2-yl)ethenyl]pyrido[1,2-a]pyrimidin-2-yl]piperidine-3-carboxamide

HRID 1238446Notes

Reaction equation

HRID 1238446 reaction equation
[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:42][NH:43][C:44](=[O:45])[CH:46]1[CH2:47][NH:48][CH2:49][CH2:50][CH2:51]1.[CH3:57][N:58]([CH3:59])[c:60]1[cH:61][cH:62][n:63][cH:64][cH:65]1.[CH3:66][N:67]([CH3:68])[CH:69]=[O:70].[ClH:41].[O:52]1[CH2:53][CH2:54][CH2:55][CH2:56]1.[OH:1][c:2]1[n:3][c:4]2[n:5]([c:6](=[O:8])[cH:7]1)[cH:9][cH:10][c:11]([CH:13]=[CH:14][c:15]1[s:16][cH:17][c:18]([CH:20]([CH3:21])[CH3:22])[n:19]1)[cH:12]2.[c:23]1([CH3:24])[cH:25][cH:26][c:27]([S:28]([Cl:29])(=[O:30])=[O:31])[cH:32][cH:33]1>>[c:2]1([N:48]2[CH2:47][CH:46]([C:44]([NH:43][CH3:42])=[O:45])[CH2:51][CH2:50][CH2:49]2)[n:3][c:4]2[n:5]([c:6](=[O:8])[cH:7]1)[cH:9][cH:10][c:11]([CH:13]=[CH:14][c:15]1[s:16][cH:17][c:18]([CH:20]([CH3:21])[CH3:22])[n:19]1)[cH:12]2

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 73974-Toluenesulfonyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 142844-(Dimethylamino)pyridineHCID 4156937N-methylpiperidine-3-carboxamideHCID 1415889712-Hydroxy-8-[2-(4-propan-2-yl-1,3-thiazol-2-yl)ethenyl]pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 69603271N-methyl-1-[4-oxo-8-[2-(4-propan-2-yl-1,3-thiazol-2-yl)ethenyl]pyrido[1,2-a]pyrimidin-2-yl]piperidine-3-carboxamide

Sources & evidence

ORD record
ord-d5b79ae1bfc2493d8ebade531cf1cea8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…