Hydrochloric Acid → HCID 57606128, compound

A solution of 5-formylthiophenecarboxylic acid (9.0 g, 57.6 mmol) in toluene (100 mL) was treated with DMF (100 μL) followed by oxalyl chloride (9.9 mL, 115 mmol) and stirred at room temperature for 3 hr then evaporated in vacuo. The crude acid chloride was then dissolved in THF (100 mL), cooled in an ice bath, and treated with a THF solution (50 mL) containing triethylamine (10 mL, 72 mmol) and piperidine (6.3 mL, 63.4 mmol). The reaction was placed in a 5° C. refrigerator for 16 hr and then treated with a 1N HCl solution (200 mL) and EtOAc (200 mL). The organic portion was further washed with a saturated aqueous solution of NaHCO3 (100 mL) followed by a brine solution (100 mL), then dried over MgSO4, filtered, and evaporated in vacuo to afford product as an oil (12.87 g, 100%). 1H NMR (CDCl3) 1.64-1.71 (m, 6 H), 3.62 (br s, 4 H), 7.31 (d, J=4.0, 1 H), 7.71 (d, J=3.5, 1 H), 9.94 (s, 1 H). 13C NMR 24.6, 26.3 (br), 44.2 (br), 49.0 (br), 128.8, 135.4, 144.8, 146.1, 162.5, 183.3. LC/MS 4.78 min, [M+1]+ 224.

1. customthen evaporated in vacuo
2. dissolutionThe crude acid chloride was then dissolved in THF (100 mL)
3. temperaturecooled in an ice bath
4. additiontreated with a THF solution (50 mL)
5. customwas placed in a 5° C.
6. customfor 16 hr
7. washThe organic portion was further washed with a saturated aqueous solution of NaHCO3 (100 mL)
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. customevaporated in vacuo

ORD record

ord-a9a616936aef43bfba16f0e15d38393a

Source dataset

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08921399B2