Nitrogen → Tert-butyl 2-[[5-(2-trimethylsilylethynyl)-3-pyridinyl]oxymethyl]azetidine-1-carboxylate

HRID 1554089Notes

Reaction equation

HRID 1554089 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([O:8][CH2:9][CH:10]2[N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:7]1.[CH3:40][Si:41]([CH3:42])([CH3:43])[C:44]#[CH:45].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[CH3:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61].[CH3:62][CH2:63][N:64]([CH2:65][CH3:66])[CH2:67][CH3:68].[Cu:48][I:49].[N:46]#[N:47].[c:21]1([P:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[c:2]1([C:45]#[C:44][Si:41]([CH3:40])([CH3:42])[CH3:43])[cH:3][n:4][cH:5][c:6]([O:8][CH2:9][CH:10]2[N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:7]1

Participants

9

Reactant 8

HCID 947NitrogenHCID 8058HexaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 18459001Tert-butyl 2-(((5-bromopyridin-3-YL)oxy)methyl)azetidine-1-carboxylate

Product 1

HCID 76371328Tert-butyl 2-[[5-(2-trimethylsilylethynyl)-3-pyridinyl]oxymethyl]azetidine-1-carboxylate

Sources & evidence

ORD record
ord-9cd704ec6727487c95ef8eab09dd59f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…