Potassium Cation → 7-(4-Ethynyl-2-fluorophenylamino)-6-fluoro-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

HRID 1572085Notes

Reaction equation

HRID 1572085 reaction equation
[C:41](=[O:42])([O-:43])[O-:44].[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH2:98]1[O:99][CH2:100][CH2:101][CH2:102]1.[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:52][OH:53].[Cu:54]([I:55])[I:56].[F:1][c:2]1[c:3](=[O:27])[n:4]2[c:8]([c:9]([C:20](=[O:21])[NH:22][O:23][CH2:24][CH2:25][OH:26])[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([I:18])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2.[K+:45].[K+:46].[O:103]=[CH:104][N:105]([CH3:106])[CH3:107].[Pd:57]([Cl:58])[Cl:59].[Si:28]([CH3:29])([CH3:30])([CH3:31])[C:32]#[CH:33].[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1.[c:79]1([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[cH:93][cH:94][cH:95][cH:96][cH:97]1>>[F:1][c:2]1[c:3](=[O:27])[n:4]2[c:8]([c:9]([C:20](=[O:21])[NH:22][O:23][CH2:24][CH2:25][OH:26])[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([C:32]#[CH:33])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2

Participants

12

Reactant 11

HCID 813Potassium Cation2×HCID 887MethanolHCID 6228DimethylformamideHCID 8028Tetrahydrofuran2×HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 66111TrimethylsilylacetyleneHCID 83717Copper iodideHCID 426062046-Fluoro-7-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

Product 1

HCID 426063207-(4-Ethynyl-2-fluorophenylamino)-6-fluoro-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

Sources & evidence

ORD record
ord-02e6c6ca1bae42f4822de083cc4945f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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