反应详情

To a solution of tert-butyl 3-(cyanomethylene)azetidine-1-carboxylate (3.0 g, 15 mmol) in tetrahydrofuran (8 mL) was added a 4.0 M solution of hydrogen chloride in 1,4-dioxane (10 mL, 40 mmol). After being stirred at room temperature for two hours, the solution was concentrated under reduced pressure. The residue was dissolved in tetrahydrofuran (20 mL). To it were added tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (3.392 g, 15.62 mmol) and triethylamine (3.126 g, 30.89 mmol). After being stirred at room temperature for 30 minutes, sodium triacetoxyborohydride (8.184 g, 38.61 mmol) was added. The mixture was stirred at room temperature overnight and diluted with aqueous NaHCO3 and EtOAc. The organic layer was separated and washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification with combi-flash (20-100% EtOAc in hexanes) afforded 0.5 g (66% yield) of the desired product. LC/MS found: 240.1 (M−56)+.

1. concentrationthe solution was concentrated under reduced pressure
2. dissolutionThe residue was dissolved in tetrahydrofuran (20 mL)
3. stirringAfter being stirred at room temperature for 30 minutes
4. stirringThe mixture was stirred at room temperature overnight
5. customThe organic layer was separated
6. washwashed with brine
7. dry with materialdried over Na2SO4
8. concentrationconcentrated under reduced pressure
9. customPurification with combi-flash (20-100% EtOAc in hexanes)