Phosphorus oxychloride → HCID 131714965, compound

HRID 1731703Notes

Reaction equation

HRID 1731703 reaction equation
P(Cl)(Cl)(Cl)=O.[N+:6]([C:9]1[CH:37]=[CH:36][C:12]([CH2:13][O:14][C:15]([CH2:17][O:18][N:19]=[C:20]([C:24]2[N:25]=[C:26]([NH:29][C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])[S:27][CH:28]=2)[C:21](O)=[O:22])=[O:16])=[CH:11][CH:10]=1)([O-:8])=[O:7].CC(O[CH2:42][C:43]1[CH2:52][S:51][C@@H:46]2[C@H:47]([NH2:50])[C:48](=[O:49])[N:45]2[C:44]=1[C:53]([OH:55])=[O:54])=O.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C.O1CCCC1.C(Cl)Cl.CN(C)C=O>[N+:6]([C:9]1[CH:10]=[CH:11][C:12]([CH2:13][O:14][C:15]([CH2:17][O:18][N:19]=[C:20]([C:24]2[N:25]=[C:26]([NH:29][C:30](=[O:35])[C:31]([F:33])([F:32])[F:34])[S:27][CH:28]=2)[C:21]([NH:50][CH:47]2[C:48](=[O:49])[N:45]3[C:44]([C:53]([O:55][CH2:13][C:12]4[CH:36]=[CH:37][C:9]([N+:6]([O-:8])=[O:7])=[CH:10][CH:11]=4)=[O:54])=[C:43]([CH2:42][S:27][CH:28]=[CH2:24])[CH2:52][S:51][C@H:46]23)=[O:22])=[O:16])=[CH:36][CH:37]=1)([O-:8])=[O:7]

Participants

9

Reactant 4

HCID 24813Phosphorus oxychlorideHCID 4413287-Aminocephalosporanic acidHCID 516892Sodium BicarbonateHCID 54112525HCID 54112525, compound

Product 1

HCID 131714965HCID 131714965, compound

Reagents, catalysts & solvents 4

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of phosphorus pentachloride-pyridine complex (prepared from phosphorus pentachloride (1.31 g) and pyridine (0.508 ml)) in methylene chloride was added p-nitrobenzyl 7-(2-phenylacetamido)-3-vinylthiomethyl-3-cephem-4-carboxylate (1.10 g) at -20° C. The mixture was stirred for 20 minutes under ice-cooling and poured into methanol (20 ml), and then an aqueous solution of sodium bicarbonate (2.1 g) was added thereto. The organic layer was separated at pH 4, washed with water, an aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride successively and dried over magnesium sulfate. The inorganic material was filtered off, and to the filtrate was added bis(trimethylsilyl)urea (5.93 g). The mixture was stirred at 30° C. for 15 minutes to give a solution of the silylated 7-aminocephalosporanic acid derivative. On the other hand, phosphorus oxychloride (0.442 g) was added to a solution of N,N-dimethylformamide (0.207 ml) in ethyl acetate (0.65 ml) under ice-cooling. The mixture was stirred at the same temperature for 30 minutes. To the mixture were added 2-(p-nitrobenzyloxycarbonylmethoxyimino)-2-[2-(2,2,2-trifluoroacetamido)thiazol-4-yl]acetic acid (syn isomer) (1.14 g), methylene chloride (55 ml) and tetrahydrofuran (2 ml) at the same temperature and the mixture was stirred for 30 minutes to give an activated acid solution. This solution was added to the solution of the silylated 7-aminocephalosporanic acid derivative at -20° C. The mixture was stirred at -20°~-10° C. for 30 minutes, poured into ice-water and adjusted to pH 7 with an aqueous solution of sodium bicarbonate. The organic layer was separated, washed with a diluted aqueous solution of sodium bicarbonate, water and a saturated aqueous solution of sodium chloride in turn, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel (25 g) column chromatography using a mixture of chloroform and methanol (50:1) as an eluent to give p-nitrobenzyl 7-[2-(p-nitrobenzyloxycarbonylmethoxyimino)-2-{2-(2,2,2-trifluoroacetamido)thiazol-4-yl}acetamido]-3-vinylthiomethyl-3-cephem-4-carboxylate (syn isomer) (1.23 g).

Workup

  1. temperaturecooling
  2. stirringthe mixture was stirred for 30 minutes
  3. customto give an activated acid solution
  4. stirringThe mixture was stirred at -20°~-10° C. for 30 minutes
  5. customThe organic layer was separated
  6. washwashed with a diluted aqueous solution of sodium bicarbonate, water
  7. dry with materiala saturated aqueous solution of sodium chloride in turn, dried over magnesium sulfate
  8. concentrationconcentrated in vacuo
  9. customThe residue was purified by silica gel (25 g) column chromatography
  10. additiona mixture of chloroform and methanol (50:1) as an eluent

Sources & evidence

ORD record
ord-16d6a0d0975843d2b2a4afcc03db623c
Source dataset
uspto-grants-1986_11
Patent number
US04622318

Reaction notes

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