Hydrochloric Acid → HCID 59198485, compound

HRID 1896547Notes

Reaction equation

HRID 1896547 reaction equation
Cl[C:2]1[C:7]2[C:8]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=3[S:10][C:6]=2[C:5]([C:19]#[N:20])=[CH:4][N:3]=1.[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1.C([O-])([O-])=O.[K+].[K+].Cl.OP([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:2]2[C:7]3[C:8]4[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][C:9]=4[S:10][C:6]=3[C:5]([C:19]#[N:20])=[CH:4][N:3]=2)=[CH:25][CH:24]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 24450Potassium Phosphate, DibasicHCID 754524-MethoxybenzylamineHCID 59198433HCID 59198433, compound

Product 1

HCID 59198485HCID 59198485, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture containing 1-chloro-7-(trifluoromethyl) [1]benzothieno[3,2-c]pyridine-4-carbonitrile, 4-methoxybenzylamine (2.2 equiv), K2CO3 (2.5 equiv) in DMF (0.15 M) was placed in a microwave reactor at 120° C. for 10 min. The reaction was diluted with H2O, the pH adjusted to 4 with HCl and K2HPO4 solution, and the title product was isolated by filtration.

Sources & evidence

ORD record
ord-2b51b68c3cb24559947cd0388069bfeb
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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