Hydrochloric Acid → 2-Fluoro-5-[2-(trimethylsilyl)ethynyl]benzenebutanenitrile

HRID 2139660Notes

Reaction equation

HRID 2139660 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:13])[c:6]([CH2:8][CH2:9][CH2:10][C:11]#[N:12])[cH:7]1.[CH2:21]([NH:22][CH2:23][CH3:24])[CH3:25].[CH3:14][Si:15]([CH3:16])([CH3:17])[C:18]#[CH:19].[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[ClH:20].[Cu:37][I:38].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30]>>[c:2]1([C:19]#[C:18][Si:15]([CH3:14])([CH3:16])[CH3:17])[cH:3][cH:4][c:5]([F:13])[c:6]([CH2:8][CH2:9][CH2:10][C:11]#[N:12])[cH:7]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8021DiethylamineHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 53434575HCID 53434575, compound

Product 1

HCID 593053672-Fluoro-5-[2-(trimethylsilyl)ethynyl]benzenebutanenitrile

Sources & evidence

ORD record
ord-dac9f163cbcb4e6b806cda3d5c77a9b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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