Hydrochloric Acid → N-[5-(4,5-dihydro-1,3-thiazol-2-yl)-1-ethyl-1,4-dihydropyrrolo[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

HRID 283051Notes

Reaction equation

HRID 283051 reaction equation
[C:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[S:44][CH2:45][CH2:46][NH2:47].[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([N:14]([S:15](=[O:16])(=[O:17])[c:18]2[s:19][cH:20][cH:21][cH:22]2)[CH3:23])[c:6]2[nH:7][c:8]([C:11]([OH:12])=[O:13])[cH:9][c:10]12.[CH3:109][N:110]([CH3:111])[CH:112]=[O:113].[CH3:114][CH2:115][N:116]([CH2:117][CH3:118])[CH2:119][CH3:120].[CH3:59][N:60]([CH3:61])[CH2:62][CH2:63][CH2:64][N:65]=[C:66]=[N:67][CH2:68][CH3:69].[Cl:105][CH2:106][Cl:107].[ClH:24].[ClH:58].[F:90][C:91]([S:92]([O:93][S:94]([C:95]([F:96])([F:97])[F:98])(=[O:99])=[O:100])(=[O:101])=[O:102])([F:103])[F:104].[OH2:108].[c:70]1([P:71](=[O:72])([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[cH:85][cH:86][cH:87][cH:88][cH:89]1.[n:48]1([OH:49])[c:50]2[cH:51][cH:52][cH:53][cH:54][c:55]2[n:56][n:57]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([N:14]([S:15](=[O:16])(=[O:17])[c:18]2[s:19][cH:20][cH:21][cH:22]2)[CH3:23])[c:6]2[nH:7][c:8]([C:11]3=[N:47][CH2:46][CH2:45][S:44]3)[cH:9][c:10]12

Participants

12

Reactant 11

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 13097Triphenylphosphine OxideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 67749Trifluoromethanesulfonic anhydrideHCID 757711-HydroxybenzotriazoleHCID 262764S-TritylcysteamineHCID 594113874-Ethyl-6-[methyl(2-thienylsulfonyl)amino]-1,4-dihydropyrrolo[3,2-b]pyrrole-2-carboxylic acid

Product 1

HCID 24880661N-[5-(4,5-dihydro-1,3-thiazol-2-yl)-1-ethyl-1,4-dihydropyrrolo[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

Sources & evidence

ORD record
ord-3e055d0dbb78479c8fa940af0280200a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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