Sodium ion → Tert-butyl 6-[9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-3-carboxylate

HRID 319742Notes

Reaction equation

HRID 319742 reaction equation
[CH3:11][C:12]([O:13][C:14]([O:15][C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])=[O:23])([CH3:24])[CH3:25].[CH3:79][N:80]([CH3:81])[c:82]1[cH:83][cH:84][n:85][cH:86][cH:87]1.[CH3:93][O:94][C:95]([CH3:96])([CH3:97])[CH3:98].[CH:70]([N:71]([CH:72]([CH3:73])[CH3:74])[CH2:75][CH3:76])([CH3:77])[CH3:78].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:6]([OH:7])=[O:8])[cH:9][n:10]1.[Cl:26][c:27]1[n:28][cH:29][c:30]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[cH:38][cH:39]1.[Cl:42][c:43]1[cH:44][c:45]([N:50]2[C:51](=[O:69])[N:52]([CH3:68])[C:53]3([C:54]2=[O:55])[CH2:56][NH:57][CH2:58][CH:59]3[c:60]2[cH:61][cH:62][c:63]([C:64]#[N:65])[cH:66][cH:67]2)[cH:46][c:47]([Cl:49])[cH:48]1.[Na+:41].[O:88]1[CH2:89][CH2:90][CH2:91][CH2:92]1.[OH-:40]>>[c:27]1([N:57]2[CH2:56][C:53]3([N:52]([CH3:68])[C:51](=[O:69])[N:50]([c:45]4[cH:44][c:43]([Cl:42])[cH:48][c:47]([Cl:49])[cH:46]4)[C:54]3=[O:55])[CH:59]([c:60]3[cH:61][cH:62][c:63]([C:64]#[N:65])[cH:66][cH:67]3)[CH2:58]2)[n:28][cH:29][c:30]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[cH:38][cH:39]1

Participants

11

Reactant 10

HCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 15413tert-Butyl methyl etherHCID 792226-Chloronicotinic acidHCID 81531DiisopropylethylamineHCID 90495Di-tert-butyl dicarbonateHCID 11521348Tert-butyl 6-chloropyridine-3-carboxylateHCID 220252984-[3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrile

Product 1

HCID 18437009Tert-butyl 6-[9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-3-carboxylate

Sources & evidence

ORD record
ord-c5a41352dcc74c25847c2c3fb911ca85
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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