Sodium Iodide → HCID 23004058, compound

Temperature

-30 °C

A solution of 5.00 g of trifluoroethanol (50.0 mmol) in 5 mL of dry THF was added dropwise, over a period of 0.5 hr, to a stirred mixture of 4.00 g of 60% dispersion of NaH (100 mmol), 1.61 g of tetrabutylammonium bromide (5.0 mmol), and 830 mg of NaI (5.0 mmol) in 20 mL of dry THF (water bath). The resulting mixture was stirred for 0.5 hrs, cooled to −30° C., and a solution of 8.23 g of ethyl 4-chloro-3-oxobutanoate (50.0 mmol) in 10 mL of dry THF was added dropwise, over a period of 15 min, to the reaction mixture. The reaction mixture was warmed to 0° C. over a period of 2 hrs, and stirred at room temperature for 36 hrs. The reaction mixture was quenched with 5 mL of ethanol, partioned between 100 mL of EtOAc and 100 mL of 10% aqueous HCl solution, separated, extracted with 2×40 mL of EtOAc, the combined organic extracts were dried (Na2SO4), and the solvent was removed in vacuo. The crude product was chromatographed on 400 g of silica packed with 5% EtOAc-hexane. The column was eluted with 5 to 25% EtOAc-hexane (1 L/5% change) to afford 8.75 g (77%) of ethyl 4-(2,2,2-trifluoroethyl)oxy-3-oxobutanoate as a slightly yellow oil. The product was used in the next step after spectral characterization.

1. temperatureThe reaction mixture was warmed to 0° C. over a period of 2 hrs
2. stirringstirred at room temperature for 36 hrs
3. customThe reaction mixture was quenched with 5 mL of ethanol
4. customseparated
5. extractionextracted with 2×40 mL of EtOAc
6. dry with materialthe combined organic extracts were dried (Na2SO4)
7. customthe solvent was removed in vacuo
8. customThe crude product was chromatographed on 400 g of silica
9. washThe column was eluted with 5 to 25% EtOAc-hexane (1 L/5% change)

ORD record

ord-56ddf2fb96ff49bda9077e6020451746

Source dataset

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06608086B2