反应详情

温度

120 °C

To a solution of 2,2,2-trifluoroethanol (40.0 g) and DMF (100 ml) was added sodium tert-butoxide (23.0 g) at 0° C. The solution was stirred at 20 to 25° C. for 1 hour at which point 2-chlorobenzoic acid (25.0 g) was added followed by cupric bromide (2.0 g). The mixture was stirred at 120° C. for 5 hours, cooled to 10° C., and water (30 ml) was added followed by 20% HCl solution (90 ml). The solution was extracted with dichloromethane (3×50 ml). The combined organic layers were washed with water (3×50 ml) and the volume was concentrated to 90 ml. Hexane (150 ml) was added to the residues, and the mixture was concentrated to volume of 120 ml and a further portion of hexane (30 ml) was added. The mixture was heated at 50° C. for 30 minutes and then stirred at room temperature for 1 hour. The solids were filtered to yield the crude product. This material was dissolved in ethyl acetate (50 ml), charcoal (1.7 g) was added and the mixture was stirred at room temperature a further 2 hours. The solution was filtered through Celite™ and crystallized from ethyl acetate/hexane to yield the pure product (30.9 g, yield 88.0%) as a white solid, m.p. 85–86° C.

1. additionwas added
2. temperaturecooled to 10° C.
3. extractionThe solution was extracted with dichloromethane (3×50 ml)
4. washThe combined organic layers were washed with water (3×50 ml)
5. concentrationthe volume was concentrated to 90 ml
6. additionHexane (150 ml) was added to the residues
7. concentrationthe mixture was concentrated to volume of 120 ml
8. additiona further portion of hexane (30 ml) was added
9. temperatureThe mixture was heated at 50° C. for 30 minutes
10. stirringstirred at room temperature for 1 hour
11. filtrationThe solids were filtered
12. customto yield the crude product
13. stirringthe mixture was stirred at room temperature a further 2 hours
14. filtrationThe solution was filtered through Celite™
15. customcrystallized from ethyl acetate/hexane