Saccharin → N-Benzylsaccharin

To a stirred solution of saccharin 82 (0.154 g, 0.75 mmol) in anhydrous THF (10 mL) at 0° C., under nitrogen atmosphere was added NaH (0.019 g, 0.8 mmol, using a 60% dispersion in mineral oil) and the resulting slurry was gradually warmed to room temperature over 1 hour period. Solvent was removed under reduced pressure, and the saccharin sodium salt was dissolved in anhydrous DMF (5 mL). To this solution, was added a solution of benzyl bromide (0.051 g, 0.3 mmol) in DMF (5 mL), under nitrogen, at room temperature and the mixture warmed to 80° C. and stirred for 4 hours. The reaction mixture was cooled to room temperature and diluted with dropwise addition of water (5 mL) and AcOEt (20 mL). The organic layer was separated and the aqueous layer extracted with AcOEt. The combined organic layer was washed with brine, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by flash column chromatography on silica gel (50% diethyl ether-hexane) to give 83.1 (0.054 g, 66% yield), as a white solid (in p 106-108° C.).

1. customSolvent was removed under reduced pressure
2. dissolutionthe saccharin sodium salt was dissolved in anhydrous DMF (5 mL)
3. temperatureunder nitrogen, at room temperature and the mixture warmed to 80° C.
4. temperatureThe reaction mixture was cooled to room temperature
5. customThe organic layer was separated
6. extractionthe aqueous layer extracted with AcOEt
7. washThe combined organic layer was washed with brine
8. dry with materialdried (MgSO4)
9. customthe solvent removed in vacuo
10. customThe residue was purified by flash column chromatography on silica gel (50% diethyl ether-hexane)

ORD record

ord-183316a36b92483bb946c08e23c77f5d

Source dataset

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09102622B2