Tetrahydrofuran → 8-Methyl-6-(4-trifluoromethyl-phenyl)-3-trimethylsilanylethynyl-imidazo[1,2-a]pyridine

HRID 803326Notes

Reaction equation

[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:22][Si:23]([CH3:24])([CH3:25])[C:26]#[CH:27].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cu:100][I:101].[I:1][c:2]1[cH:3][n:4][c:5]2[n:6]1[cH:7][c:8](-[c:12]1[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]1)[cH:9][c:10]2[CH3:11].[Pd:59]([Cl:60])[Cl:61].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1.[c:81]1([P:82]([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)[cH:95][cH:96][cH:97][cH:98][cH:99]1>>[c:2]1([C:27]#[C:26][Si:23]([CH3:22])([CH3:24])[CH3:25])[cH:3][n:4][c:5]2[n:6]1[cH:7][c:8](-[c:12]1[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]1)[cH:9][c:10]2[CH3:11]