Water → HCID 9898926, compound

Temperature

60 °C

Triphenylphosphine (380 mg, 1.5 mmol) was dissolved in TBF (20 mL), then argon was bubbled through the solution for several minutes to deoxygenate it. Palladium(II) acetate (82 mg, 0.37 mmol) was added, and the reaction mixture was heated to 60° C. for 0.5 h, and then cooled to ambient temperature. CuI (210 mg, 1.1 mmol), 2-bromo-1,3-thiazole (1.6 g, 9.8 mmol), potassium carbonate (4.2 g, 31 mmol) and water (0.70 mL, 39 mmol) were dissolved in DME (30 mL) and argon was bubbled through the mixture for several minutes to deoxygenate the mixture. 3,3-dimethyl-1-butyne (1.0 g, 12.2 mmol) was then added to mixture. The catalyst solution of triphenylphosphine and palladium (II) acetate in THF was added to the reaction flask which was heated to 30° C. for 2 h. After this time heating was discontinued and the mixture was allowed to stir at ambient temperature. After stirring for 16 h, GC/MS analysis showed the reaction to be complete. The mixture was filtered through Celite.™., the filter pad was washed thoroughly with ethyl acetate, and the combined filtrates were concentrated in vacuo. The residue was dissolved in ethyl acetate (200 mL), washed with water (200 mL), brine (200 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography eluting with hexane, then 99:1 hexane:ethyl acetate to afford 2-(3,3-dimethyl-1-butynyl)-1,3-thiazole (0.45 g, 28% yield) as a yellow oil. 1H NMR (CDCl3, 300 MHz) Δ7.74 (d, J=3.0 Hz, 1H), 7.28 (d, J=3.0 Hz, 1H), 1.33 (s, 9H). MS (ESI) 166.1 (M++H).

1. customargon was bubbled through the solution for several minutes
2. customto deoxygenate it
3. temperaturecooled to ambient temperature
4. customargon was bubbled through the mixture for several minutes
5. customto deoxygenate the mixture
6. temperaturewas heated to 30° C. for 2 h
7. temperatureAfter this time heating
8. stirringAfter stirring for 16 h
9. customthe reaction
10. filtrationThe mixture was filtered through Celite
11. wash, the filter pad was washed thoroughly with ethyl acetate
12. concentrationthe combined filtrates were concentrated in vacuo
13. dissolutionThe residue was dissolved in ethyl acetate (200 mL)
14. washwashed with water (200 mL), brine (200 mL)
15. dry with materialdried over Na2SO4
16. filtrationfiltered
17. concentrationconcentrated in vacuo
18. customThe residue was purified by column chromatography
19. washeluting with hexane

ORD record

ord-6e9439eddff1484b9fb605d4281e2e81

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07462619B2